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Congress contribution in 2021

SABCS: San Antonio Breast Cancer Symposium, December 7-10, 2021

  • Gerber B, Stachs A, Veselinovic K et al. Patient-reported outcomes (PROs) for the intergroup sentinel mamma study (INSEMA, GBG75, ABCSG43): Persistent impact of axillary surgery on arm and breast symptoms in early breast cancer. SABCS 2021; abstract GS4-03, oral presentation.
    Denkert C, Marmé F, Martin M, et al. Molecular plasticity of luminal breast cancer and response to CDK 4/6 inhibition - The biomarker program of the PENELOPE-B trial investigating post-neoadjuvant palbociclib. SABCS 2021; abstract PD2-04, poster discussion.
  • Wege AK, Vladimirova V, Solbach C, et al. Mdm2 gene amplification in estrogen receptor-positive breast cancer cells is associated with enhanced solid tumor growth and pronounced metastatic potential in humanized tumor mice (HTM) and a poor outcome of patients with luminal breast cancer. SABCS 2021; abstract PD9-07, poster discussion.
  • Marmé F, Schmidt M, Furlanetto J, et al. Phase III postneoadjuvant study evaluating sacituzumab govitecan (SG), an antibody drug conjugate in primary HER2-negative breast cancer patients with high relapse risk after standard neoadjuvant treatment – SASCIA. SABCS 2021; abstract OT1-02-01, TIP.
  • Galas K, Gleitsmann M, Rey J, et al. Immunological markers in patients with breast cancer occurring during pregnancy - Results from GBG BCP study. SABCS 2021; abstract P4-04-14, poster.
  • Loibl S, Hauke J, Gelmon K, et al. Germline BRCA1/2 and other predisposition genes in high-risk early-stage HR+/HER2- breast cancer (BC) patients treated with endocrine therapy (ET) with or without palbociclib: A secondary analysis from the PENELOPE-B study. SABCS 2021; abstract P5-13-36, poster.
  • Regan MM, Walley BA, Fleming GF, et.al. Randomized comparison of adjuvant aromatase inhibitor exemestane + ovarian function suppression (OFS) vs tamoxifen + OFS in premenopausal women with hormone receptor-positive (HR+) early breast cancer: update of the TEXT and SOFT trials. SABCS 2021; abstract GS2-05, oral presentation.
  • Gnant M, Dueck AC, Frantal S, et al. Adjuvant palbociclib in HR+/HER2- early breast cancer: Final results from 5,760 patients in the randomized phase III PALLAS trial. SABCS 2021; abstract PD2-09, poster discussion.
  • Naughton MJ, Zahrieh D, Gnant M, et al. Quality of life and symptom severity in the PALLAS randomized trial of palbociclib with adjuvant endocrine therapy in early breast cancer (AFT-05). SABCS 2021; abstract P4-10-01, poster.
  • Ganz PA, Bandos H, Spanic T, et al. Quality of life results from OlympiA: A phase III, multicenter, randomized, placebo-controlled trial of adjuvant olaparib after (neo)-adjuvant chemotherapy in patients with germline BRCA1/2 mutations and high-risk HER-2 negative early breast cancer. SABCS 2021; abstract GS4-09, oral presentation.
  • Geyer, Jr CE, Untch M, Prat, et al. Trastuzumab deruxtecan (T-DXd; DS-8201) vs trastuzumab emtansine (T-DM1) in high-risk patients with HER2-positive, residual invasive early breast cancer after neoadjuvant therapy: A randomized, phase 3 trial (DESTINY-Breast05). SABCS 2021; abstract OT1-02-03, TIP.
  • Loibl S, Tolaney SM, Punie K, et al. Assessment of health-related quality of life by clinical response from the phase 3 ASCENT study in metastatic triple‑negative breast cancer (mTNBC). SABCS 2021; abstract P5-16-01, poster.

ESMO: European Society for Medical Oncology, September 16-21, 2021, Virtual Meeting

  • Loibl S, Schmidt M, Lübbe K, et al. A multicenter, randomized, double-blind, phase II study to evaluate the tolerability of an induction dose escalation of everolimus in patients with metastatic breast cancer (mBC) (DESIREE). Ann Oncol. 2021; 32 (suppl_5): S1292-S1293, LBA19 mini oral presentation.
  • García-Saenz J, Marmé F, Rugo H, et al. Quality of life from the Penelope-B study on high-risk HR+/HER2- early breast cancer patients treated with endocrine therapy with or without palbociclib. Ann Oncol. 2021; 32 (suppl_5): S407-S446, 122MO mini oral presentation.
  • Galactionova K, Loibl S, Salari P, et al. Health economic properties of Palbociclib in breast cancer patients with high risk of relapse following neoadjuvant therapy – results from the Penelope-B trial. Ann Oncol. 2021; 32 (suppl_5): S407-S446, 132P ePoster.
  • Marmé F, Hanusch C, Furlanetto J, et al. Phase III postneoadjuvant study evaluating Sacituzumab Govitecan (SG), an antibody drug conjugate in primary HER2-negative breast cancer patients with high relapse risk after standard neoadjuvant treatment – SASCIA. Ann Oncol. 2021; 32 (suppl_5): S407-S446, 199TiP ePoster.
  • Loibl S, Sikov W, Huober J, et al. Event-free survival (EFS), overall survival (OS), and safety of adding veliparib (V) plus carboplatin (Cb) or carboplatin alone to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) after ≥4 years of follow-up: BrighTNess, a randomized Phase 3 trial. Ann Oncol. 2021; 32 (suppl_5): S408, 119O oral presentation.
  • Loibl S, Loirat D, Tolaney SM, et al. Health-related quality of life (HRQoL) in the ASCENT study of sacituzumab govitecan (SG) in metastatic triple-negative breast cancer (mTNBC). Ann Oncol. 2021; 32 (suppl_5): S457-S515, 257P ePoster.
  • Franzoi MA, Martel S, Agbor-Tarh D, et al. Impact of body mass (BMI) and weight change after adjuvant treatment in patients (pts) with HER2-positive early breast cancer. Ann Oncol. 2021; 32 (suppl_5): S415-S416, 131P ePoster.

Senologiekongress 2021, June 17-19, 2021, Virtual Meeting

  • Laakmann E, Witzel I, Neunhöffer T et al. Characteristics of patients with brain metastases from HER2-positive breast cancer. oral presentation.
  • Untch M, Geyer Jr CE, Prat A, et al. Trastuzumab-Deruxtecan (T-DXd; DS-8201) vs trastuzumab emtansine (T-DM1) in high-risk patients with HER2-positive, residual invasive early breast cancer (BC) after neoadjuvant therapy (NAT): a randomized, phase 3 trial (DESTINY-Breast05). TIP

ASCO: American Society of Clinical Oncology, Annual Meeting June 4-8, 2021, Virtual Meeting

  • Loibl S, Schneeweiss A, Huober J, et al. Durvalumab improves long-term outcome in TNBC: results from the phase II randomized GeparNUEVO study investigating neodjuvant durvalumab in addition to an anthracycline/taxane based neoadjuvant chemotherapy in early triple-negative breast cancer (TNBC). J Clin Oncol. 2021; 39.15_suppl.506, oral presenation.
  • Denkert C, Marmé F, Matrtin M, et al. Subgroup of post-neoadjuvant luminal-B tumors assessed by HTG in PENELOPE-B investigating palbociclib in high risk HER2-/HR+ breast cancer with residual disease. J Clin Oncol. 2021; 39.15_suppl.519, poster discussion.
  • Marmé F, Martin M, Untch M, et al. Palbociclib combined with endocrine treatment in breast cancer patients with high relapse risk after neoadjuvant chemotherapy: Subgroup analyses of premenopausal patients in PENELOPE-B. J Clin Oncol. 2021; 39.15_suppl.518, poster discussion.
  • Amant F, Nekljudova V, Maggen C, et al. Outcome of breast cancer patients treated with chemotherapy during pregnancy compared with non-pregnant controls. J Clin Oncol. 2021; 39.15_suppl.515, poster discussion.
  • Marmé F, Stickeler E, Furlanetto J, et al. Phase III postneoadjuvant study evaluating sacituzumab govitecan, an antibody drug conjugate in primary HER2-negative breast cancer patients with high relapse risk after standard neoadjuvant treatment: SASCIA. J Clin Oncol. 2021; 39.15_suppl.TPS602, TIP.
  • De Azambuja E, Eiger D, Procter MJ, et al. Cardiac safety of dual anti-HER2 blockade with pertuzumab plus trastuzumab (P+T) in the APHINITY trial. J Clin Oncol. 2021; 39.15_suppl.510, poster discussion.
  • Tutt A, Garber JE, Kaufman B et al. OlympiA: A phase III, multicenter, randomized, placebo-controlled trial of adjuvant olaparib after (neo)adjuvant chemotherapy in patients with germline BRCA1/2 mutations and high-risk HER2-negative early breast cancer. J Clin Oncol. 2021; 39.15_suppl. LBA1, oral presentation.
  • Kalinsky K, Oliviera M, Traina TA, et al. Outcomes in patients (pts) aged ≥65 years in the phase 3 ASCENT study of sacituzumab govitecan (SG) in metastatic triple-negative breast cancer (mTNBC). J Clin Oncol. 2021; 39.15_suppl.1011, oral presentation.
  • Carey LA, Loirat D, Punie K, et al. Assessment of sacituzumab govitecan (SG) in patients with prior neoadjuvant/adjuvant chemotherapy in the phase 3 ASCENT study in metastatic triple-negative breast cancer (mTNBC). J Clin Oncol. 2021; 39.15_suppl.1080, ePoster.
  • Curligliano G, Mueller V, Borges VF, et al. Updated results of tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases (HER2CLIMB). J Clin Oncol. 2021; 39.15_suppl. 1043, ePoster.

ESMO-Breast Cancer May 5-8, 2021, Virtual Meeting

  • Llop-Guevara A, Vladimirova V, Schneeweiss A et al. Association of RAD51 with Homologous Recombination Deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial. Ann Oncol. 2021; 32 (suppl_2): S21-S36, O2 oral presentation.
  • Laakmann E, Witzel I, Neunhöffe T et al. Characteristics of patients with brain metastases from HER2-positive breast cancer. Ann Oncol. 2021; 32 (suppl_2): S60-S78, 95MO mini oral presentation.
  • Furlanetto J, Denkert C, Untch M, et al. Impact of body mass index (BMI) on prognostic and predictive value of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC): a pooled analysis of six neoadjuvant trials. Ann Oncol. 2021; 32 (suppl_2): S27-S28, 17P ePoster.
  • Vladimirova V, Schneeweiss A, Jackisch C, et al. BACH1 and HIF1α predict response to neoadjuvant nab-paclitaxel (nP) treatment in early breast cancer (BC). Ann Oncol. 2021; 32 (suppl_2): S29, 21P ePoster.
  • Leichsenring J, Vladimirova V, Solbach C, et al. EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy. Ann Oncol. 2021; 32 (suppl_2): S32, 28P ePoster.
  • Labidi-Galy I, Schneeweiss A, Sinn HP, et al. Baseline menopausal status, Ki-67 and stromal tumor-infiltrating lymphocytes (TILs) and association with outcome in triple-negative breast cancer (TNBC): exploratory analysis in GeparSixto. Ann Oncol. 2021; 32 (suppl_2): S49-S50, 66P ePoster.

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